Great review on the literature of LC-MS/MS and now the new ESI-MS/MS method in saliva hormone testing. This technique is highly sensitive and specific. This article goes through the literature support for each hormone. It also discusses how/why saliva testing is valid. Conclusion: "the author believes that the saliva-based hormone test will be integrated into clinical practice in the near future".
salivary testosterone and DHEA evaluation by LC-MS/MS validated and shown to be applicable in the diagnosis and therapy in those men with low testosterone and DHEA.
Morning salivary cortisol is as good as serum as screening test for patients with Addison's disease and nighttime salivary cortisol is more adequate than serum in the screening of Cushing's syndrome.
saliva testing is the new "gold standard" for hormone evaluation. No testing method is perfect and thus there are guidelines for salivary collections. However, saliva is equal too or superior to blood for hormone evaluation.
Salivary cortisol testing used to evaluate cortisol pattern in those with metabolic syndrome. In this study, they found no difference in cortisol pattern in people with metabolic syndrome.
The measurement of salivary cortisol is a useful tool for physiological studies and for the diagnosis of CS in children and adults on an outpatient basis
Sampling for salivary cortisol determination is a sensitive, specific and pain-free procedure and it is therefore very useful for following healthy and sick children before, during and after pharmacological interventions
Salivary progesterone profiles derived from daily sampling of 20 infertile patients not only allowed accurate assessment of ovarian dysfunction but also indicated more effectively than conventional techniques the change in hormonal status following ovulation induction therapy with clomiphene citrate or bromocriptine.
salivary cortisol testing recommended as first-line test for Cushing's syndrome due to "high diagnostic accuracy". So, I wonder why so many state medical boards and insurance companies have missed this one?
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